Melanotan 2

What Is Melanotan‑2?

Melanotan‑2 is a synthetic cyclic heptapeptide designed as an analog of the endogenous α‑melanocyte‑stimulating hormone (α‑MSH). It was developed to mimic natural melanocortin activity, particularly in stimulating melanin production for photoprotection. Beyond pigmentation, Melanotan‑2 has been studied for its effects on appetite regulation, energy balance, and sexual function.

Mechanism of Action

Melanotan‑2 binds to melanocortin receptors (MC1R, MC3R, MC4R, and MC5R). Activation of MC1R in melanocytes stimulates melanin synthesis, resulting in increased skin pigmentation and enhanced UV protection. MC4R activation in the hypothalamus influences appetite suppression and energy regulation, while MC3R and MC5R pathways contribute to metabolic and neuroendocrine modulation. Notably, MC4R stimulation has been linked to pro‑erectile effects, leading to investigational interest in sexual dysfunction therapies.

Research & Clinical Data

Preclinical and limited clinical studies suggest Melanotan‑2’s efficacy in inducing tanning, reducing appetite, and modulating sexual function. It has been investigated as a potential therapy for erectile dysfunction and obesity. However, regulatory approval has not been granted, and its use remains restricted to research contexts. Reports of side effects include nausea, flushing, and changes in pigmentation patterns. Despite commercial availability in unregulated markets, official medical use is not authorized.

Purity & Quality

Reference‑grade peptide material. Certificate of Analysis available per batch. Regulatory status: investigational, not FDA‑ or EMA‑approved.

Classification & Handling Class: Synthetic cyclic heptapeptide | Target: Melanocortin receptors (MC1R–MC5R) | Administration: Subcutaneous injection | Storage: 2–8°C refrigerated, protect from light | Regulatory: Not FDA/EMA approved