5 Amino 1MQ

What Is 5-Amino-1MQ?

5-Amino-1MQ (5-Amino-1-methylquinolinium) is a synthetic small-molecule compound classified as a selective inhibitor of Nicotinamide N-methyltransferase (NNMT) — an enzyme overexpressed in adipose and hepatic tissue under conditions of metabolic dysfunction. Unlike peptide-based research compounds, 5-Amino-1MQ’s small-molecule structure confers favorable membrane permeability and oral bioavailability, distinguishing it mechanistically from injectable secretagogues.

Mechanism of Action
5-Amino-1MQ competitively inhibits NNMT, thereby blocking the methylation of nicotinamide into N-methylnicotinamide (MNA). This inhibition preserves intracellular nicotinamide pools, elevating NAD⁺ availability. Increased NAD⁺ levels subsequently enhance the activity of NAD⁺-dependent enzymes — including Sirtuin-1 (SIRT1) and poly(ADP-ribose) polymerases (PARPs) — and activate downstream AMPK-driven energy sensing pathways. Preclinical transcriptomic data further suggests upregulation of mitochondrial biogenesis markers including UCP1 and PRDM16 in white adipose tissue.

Research Applications
In laboratory settings, 5-Amino-1MQ is investigated in the context of:

• NAD⁺ metabolism research — examining intracellular cofactor dynamics and sirtuin pathway regulation
• Metabolic signaling studies — investigating NNMT-driven changes in SIRT1/AMPK phosphorylation
• Adipose tissue biology — studying phenotypic shifts in white-to-brown adipose tissue gene expression
• Muscle stem cell research — evaluating satellite cell rejuvenation and fusion capacity in aged murine models

Purity & Quality
Synthesized to ≥98% purity, verified by HPLC. Each batch ships with a full Certificate of Analysis. All data referenced is derived from preclinical murine and in vitro models; no peer-reviewed human clinical trials have been published to date.

Molecular Formula: C₁₀H₁₀N₂ | Molecular Weight: 174.20 g/mol | Compound Class: NNMT Inhibitor (Small Molecule) | Storage: -20°C (lyophilized) or 4°C (short-term)